A metal-free approach for the synthesis of amides/esters with pyridinium salts of phenacyl bromides via oxidative C–C bond cleavage

• Kesari Lakshmi Manasa,
• Yellaiah Tangella,
• Namballa Hari Krishna and
• Mallika Alvala

Beilstein J. Org. Chem. 2019, 15, 1864–1871, doi:10.3762/bjoc.15.182

• functional group tolerance, broad substrate scope and operational simplicity are the prominent advantages of the current protocol. Keywords: amidation; benzoylation; benzylamines; pyridinium salt of phenacyl bromides; Introduction Amidation and esterification are fundamental transformations in synthetic

• electron-donating groups on both the aryl moieties of the pyridinium salt of phenacyl bromides and benzylamines were well tolerated and delivered the corresponding products in good yields. The electron-rich pyridinium salts of phenacyl bromides reacted smoothly with the amines and furnished the